c-MYC anticorps (C-Term) (CF®405S)

N° du produit ABIN6175742

Cet anticorps anti-c-MYC est un anticorps Souris Monoclonal détectant c-MYC dans IF et FACS. Adapté pour Humain, Chimpanzé et Gorilla.

Aperçu rapide pour c-MYC anticorps (C-Term) (CF®405S) (ABIN6175742)

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivité: Humain, Chimpanzé, Gorilla

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp c-MYC est conjugé à/à la CF®405S

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: CT14-G4

Détail du produit anti-c-MYC anticorps (CF®405S)

Épitope: AA 408-439, C-Term

Fonction: Mouse Monoclonal anti-c-Myc (CT14.G4), CF405S Conjugate

Attributs du produit: The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQL-RNSCA) from C-terminus of human c-myc, coupled to KLH

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow Cytometry 0.5-1 μg/million cells/0.1 mL

• Immunofluorescence 1-2 μg/mL
• Does not react with mouse, others not known
• Optimal dilution for a specific application should be determined by user

Commentaires:

HL-60 cells or breast carcinoma

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur c-MYC

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Autre désignation: c-Myc

Poids moléculaire: 62-64 kDa

ID gène: 4609, 202453

UniProt: P01106

Pathways: Signalisation p53, Cycle Cellulaire, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, L'effet Warburg